Never tried a Mike but a mic yes ... I only discovered by accident. You will not get the best results but yes you can. I am able to sing a note and get the Midi Guitar, interfaced with Logic Pro X, to record a soft instrument single note or a chord. BTW this isn't rocket science to use, you just have both apps running and it 'just works'. Obviously use head phones to avoid feed back if you use a mic. If you use a Mike all bets are off. LOL.