I've got some interesting information on the flu vaccine generation, and the reasons why we have the current shortage:
Production schedule
Aug (of previous year): Company contracts ~50 chicken farms to produce fertilized eggs. Laying starts on december.
Jan-May: The CDC provides live seed viruses for strains it thinks will be present. Usually three strains are selected.
Companies inoculate ~12-day-old eggs. Virus grows in developing embryo for three days. Each egg generates six doses for each virus, but since each virus must be grown separately, effectively two doses per egg. Fluid is collected, and virus is inactivated through formaldehyde crosslinking.
June-July: Purity and quanity is checked, all sorts of strict purity assurances.
Aug-Sept: Pack and ship vaccines.
Oct-Nov: Begin Vaccinations.
Here's the problem: The companies only get one shot at this each year, because the process starts the year before. If one step is screwed up, you're hosed.
Evidently what happened this year was that Aventis, the only manufacturer in the US, had a mass serratia contamination in their egg cultures.
Several years ago there used to be 27 companies making vaccines, but now only five. In 2002, Wyeth (the other US manufacturer) quit making them because 12 million doeses were not used by the public, causing lots of revenue loss.
Considering that over a billion doses of the flu vaccine are made each year, you would think that there would be some stockpile, but because of the extremely stringent quality assurance required, companies only make as much as necessary.
Technically, it's no ones fault, it just happens to be a domino effect. Other methods exist for making vaccines, but the problem is that they have to go through massive FDA approval steps (since the vaccines are used in so many people) that the cost is almost prohibitive.
Moral of the story: One of the reasons american prescription drugs cost more than canadian drugs is because we pay a lot (read all) of the research costs. The more people who buy cheap drugs, the less money avalible for research. However, Pfizer made over a billion dollars on Viagra (a fix for a "disease" that never killed anybody), so pointing fingers is rather difficult.
Production schedule
Aug (of previous year): Company contracts ~50 chicken farms to produce fertilized eggs. Laying starts on december.
Jan-May: The CDC provides live seed viruses for strains it thinks will be present. Usually three strains are selected.
Companies inoculate ~12-day-old eggs. Virus grows in developing embryo for three days. Each egg generates six doses for each virus, but since each virus must be grown separately, effectively two doses per egg. Fluid is collected, and virus is inactivated through formaldehyde crosslinking.
June-July: Purity and quanity is checked, all sorts of strict purity assurances.
Aug-Sept: Pack and ship vaccines.
Oct-Nov: Begin Vaccinations.
Here's the problem: The companies only get one shot at this each year, because the process starts the year before. If one step is screwed up, you're hosed.
Evidently what happened this year was that Aventis, the only manufacturer in the US, had a mass serratia contamination in their egg cultures.
Several years ago there used to be 27 companies making vaccines, but now only five. In 2002, Wyeth (the other US manufacturer) quit making them because 12 million doeses were not used by the public, causing lots of revenue loss.
Considering that over a billion doses of the flu vaccine are made each year, you would think that there would be some stockpile, but because of the extremely stringent quality assurance required, companies only make as much as necessary.
Technically, it's no ones fault, it just happens to be a domino effect. Other methods exist for making vaccines, but the problem is that they have to go through massive FDA approval steps (since the vaccines are used in so many people) that the cost is almost prohibitive.
Moral of the story: One of the reasons american prescription drugs cost more than canadian drugs is because we pay a lot (read all) of the research costs. The more people who buy cheap drugs, the less money avalible for research. However, Pfizer made over a billion dollars on Viagra (a fix for a "disease" that never killed anybody), so pointing fingers is rather difficult.
The secret of life: Proteins fold up and bind things.
The secret of life: Proteins fold up and bind things.








Where's Laurie Dhue?! We got some celebratin' to do! 
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Think about it! If it is remotely plausible then it is most certainly the correct explanation.
Aiyeee! Hold me, Scully! Hold me until the fear in me subsides...

