iSquint just streamlines FFMPEGX, so, it can handle VIDEO_TS, just differently. Handbrake will take an entire DVD's video_ts files and make one movie file, while iSquint would process each video_ts file separately. I like them both, for different reasons. For anything I'd consider firing up FFMPEGX to encode, I try iSquint first. I use Handbrake for DVDs and disc images.