USB And Line Out Audio Output

in Genius Bar edited January 2014
I'm going to be setting up my Mac Mini to 2 different audio sources. I want my DVD movies to play through the TV speakers and I want iTunes to play music through the home stereo system.

Is it possible to use the Audio Line Out on the MacMini AND use a USB Audio device (iMic USB Audio Interface) connected to my home stereo at the same time?

Can you have 2 Audio output devices on 1 machine?

With Sound prefences, can I setup my Mac to play audio from Itunes through the USB Audio output? AND when I watch a DVD on my MacMini, can it play audio through the TV speakers? (I'm using a plasma TV with built in speakers as the display for my Mac Mini). Anyone know?
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