I'm going to go out ona limb and say that we will see a replacement for the mouse with...a multitouch mousepad. The Cult of Mac blog put forth this notion and I agree 100%. Of course, it'll come bundled with the new iMac!
A multitouch keyboard/mouse could merge all input functions into one thin virtual device which could change its own screen formats in thousands of ways, a la iPhone interface (on viagra). Not a keyboard, not a mouse, something different and much better.
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