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May I speak to the CMYK concerns, as someone who consults on best practices for these workflows regularly?
Best practice for almost all workflows is to retouch in the original (almost always) RGB color space, and only convert to CMYK at the end of the process. The reason for this?
In a contemporary workflow, the final destination for this carefully retouched file will, in fact, be multiple destinations, some of them RGB, some of them various flavors of CMYK. For way too long, retouchers would routinely convert their original files to whatever default setting their copy of Photoshop was using for CMYK. Very frequently, this setting was a serious mismatch for the CMYK that was actually going to be used to print, so the color conversion created multiple problems through out the workflow, even when only CMYK was used for output.
A standard response to hearing people say that they work in CMYK is to ask "Which one?", since each combination of press, ink and paper is going to be a different flavor of CMYK.Ah, but you say, I need to see how it's going to convert in order to retouch it correctly. If you're working in Photoshop, you can preview how it's going to look in different flavors of CMYK with a keystroke or two, comparing how it will look in CMYK for newsprint, for example, against how it will look in CMYK for a glossy fashion magazine, versus a large banner, versus how it will look in RGB prepared for the internet.
Then, when the editing/retouching is all finished, the quality of the original image has been preserved, and can be correctly converted for each destination device's best color. Converting to CMYK at the front end of the process is a guaranteed way to settle for lowest-common-denominator color. Why would you want that in 2017 and beyond when it is so easy to do it correctly?
In 2017, anyone who's converting files to CMYK at the front of the workflow is settling for less than they could have, instead of going for maximum quality, and should seriously rethink their approach.
Should you want to use Pixelmator Pro, and it turns out not to convert to CMYK, multiple conversion tools exist to convert your file quickly and easily, some built into your Mac already...